Manufacturer specifications 2991 cell processor, cobe. Terumo bct is the world leader in blood component technologies. The presented cobe cooling systems can easily be adapted to a cobe 2991 cell separator and are efficient in maintaining gradient solutions at a defined low temperature during centrifugation. Connect the cell product bag and processingwashing solution containers to the cell processing disposable set. After centry tpe was introduced in 1981, cobe delved further into this area with its 1984 acquisition of ibms biomedical systems division. Medical laboratory equipment for sale miga medical. To remove red blood cells and platelets, manual ficoll density gradient centrifugation is applied in early reports and again in more recent clinical trials nct01886976. Cobe 2991 blood cell processor centrifuge cell washer operations manual. As a result, several attempts have been made to cool the cobe 2991 cell. Products were to be allowed to warm to room temperature before processing.
Customs services and international tracking provided. In the case of frozen, thawed blood, the blood was washed to remove the cryogenic agent, typically, glycerol. The processor washed fresh blood or frozen, thawed blood. Watch the cobe 2991 cell processing procedure, stepbystep. Scott breslow private tutor private tutoring linkedin. Densitygradient separation for 4hydroperoxycyclophosphamide purging of autologous.
From timetested deglycerolization procedures to bone marrow processing, the cobe 2991 cell processor has been a solid solution for a. Used cobe 2991 blood cell processor cell separator for sale. Hypotensive transfusion reaction treated with vasopressin. Standard operating procedure of the nih clinical islet. Human bone marrow processing using cobe 2991 and cs 3000 blood cell separators for further ex vivo. Alternatively, automated cell washers such as the cobe 2991 cell processor. The increase in global cell therapy research, cuttingedge clinical trials and advances in laboratory operations all give rise to the importance of this.
We have changed our process to better align with current agency policy. At this point in the surgery, the patients need for a blood transfusion was becoming marked. Buffycoat cells were isolated primarily either using the cobe 2991 blood cell processor or haemonetics 30 cell separator. Products not being infused are discarded unless they have correct transfer paperwork, i. It was first marketed by ibm systems supplies division ssd in 1972. Terumo bct receives fda approval to conduct an evaluation of its polymorphonuclear cell collection protocol. As the flexible diaphragm inflates, it presses against the bottom of the cell processing bag.
We have the cobe 2991 cell washer and support 1 patient at our facility with washed red cells every 23 weeks. Cobe 2991 cell processor powers up in bma uk july specialist medical equipment a. Red cells are glycerolized, deglycerolized, and washed in a closed disposable system and automatically resuspended in additive solution to permit extended product storage post washing. Sep 23, 1997 in a preferred, nonlimiting specific embodiment of the invention, the host instrument is a cell washing apparatus such as a cobe 2991 blood cell processor. Manufacturer specifications 2991 cell processor, cobe cardiovascular please note. This method however is much more expensive than automated washing. The clinimacs prodigy is a closed and automated platform with the capability to manufacture various cell types on a single device and within a single process setup. Validation procedure for cell washer transfusion services. The blood and marrow transplant clinical trials network bmt ctn. My question is in regard to the equipment qcshould there be a sterility check. Automated processing puts control at the user s fingertips. Established design the cobe 2991 cell processor has been designed to facilitate superior performance and operational reliability.
Does anyone use the cobe 2991 cell processor to wash apheresis platelets. Our procedure for washing prbcs involves the use of a cobe 2991 cell processor rontis ag, zug, switzerland. Pdf comparing cooling systems for the cobe 2991 cell separator. What is the price of a replacement cobe 2991 blood cell processor. Terumo bct launches mononuclear cell collection protocol. The cobe 2991 cell processor provides operational reliability using automation for control and consistency. Characteristics of clinimacs system cd34enriched t cell. Densitygradient separation for 4hydroperoxycyclophosphamide purging of autologous bone marrow grafts. The cobe 2991 cell processor offers an alternative to laborintensive methods for the separation of cell products, such as manually layering blood over a density. Cobe 2991 washing apheresis platelets sign in to follow this. Beyond the list of terumo bctvalidated protocols, customers continue to establish new uses for the device. Cobe 2991 cell washer removed in good condition, untested, sold as is.
It earned its enviable reputation for reliability, ease of use, instrument consistency, disposable set performance and multi. I can not find any literature stating the standard for acceptanc. Whatever the application, almost all cell processing procedures on the cobe 2991 cell processor follow these basic steps. Jan 03, 2019 in a survey of 15 childrens hospitals 150400 beds across america, 14 out of 15 hospitals used the cobe 2991 cell processor terumo bct, lakewood, co, usa, making it one of the most popular processors in the field. This processor is a user definable system derived from the clinical cell selection device isolex. Cobe cardiovascular 2991 cell processor cell saver for sale.
The customer reported that while performing super out on a bone marrow procedure using a cobe 2991 cell processor, the. Full text traditional and emerging technologies for washing. You need to be registered and approved to bid at this. Autologous red blood cell salvage is a safe, reliable and costeffective method of returning washed red blood cells to a patient. Aug 29, 2011 centers 1, 2, and 6 used the cobe 2991 cell washer, whereas the other centers used blood transfer bags and a centrifuge bag method for the wash steps. Used cobe 2991 blood cell processor cell separator for. Your bid or registration is pending approval with the auctioneer.
The cobe 2991 cell processor set the industry standard more than 30 years. Introduced more than 30 years ago, the cobe 2991 cell processor has set t he industry standard as a reliable laboratory tool for a variety of cell processing applications. Several aspects of cell therapy manufacturing will have an impact on product quality and cogs. Its a long short but does anyone know another company other than terumobct that can calibrate a cobe 2991 cell processor. Our acp 215 automated cell processor provides a safe, simple way to freeze, thaw, and wash red blood cells. Cobe cpc system community, manuals and specifications. Our current quality control procedure is 80% red cell recovery using pre and post hematocrits on the unit that is washed. Traditional and emerging technologies for washing and volume.
The reliable cobe 2991 cell processor and disposables offer operational reliability and proven cell washing performance. Perform protocols efficiently with automation or the flexibility to use manual controls. Automated processing puts control at the users fingertips. Gambro bcy cobe 2991 blood cell bone marrow processor separation centrifuge power cord due to the size and weight of this item, it will need to be freighted. Watch a cell processing procedure from start to finish.
The acquisition brought products that became known as the cobe 2991 cell processor and the cobe 2997 blood cell separator, both used for blood component therapy. Used cobe gambro bcy 2991 processor centrifuge cell washer. Post a free request for proposal for a cobe 2991 blood cell processor cell separator and get quotes from our gold service dealers. By placing this bid you agree to all terms and conditions governing this particular auction. Neither cobe 2991 nor acp 215 can remove these activated cells and. We believe in the potential of blood to do even more for patients than it does today. View scott breslows profile on linkedin, the worlds largest professional community. Platelet and antibody wash steps could be performed using a bag method as described in the clinimacs manual or by using a cobe 2991 cell washer. Pdf comparing cooling systems for the cobe 2991 cell. You need to be registered and approved to bid at this auction. The ibm 2991 blood cell processor was a blood cell washer developed by ibm systems development division in endicott, ny.
Set up the cobe according to the operational manual and the institutions procedures. This report is being filed as a result of changes to our mdr evaluation process. The processing of stem cell concentrates from the bone. Several vendors provide fully automated and closed systems suitable for cell therapy applications. Somith verma clinical manufacturing associate hitachi. Automatic sample preparation system for cellular therapy for blood. See the complete profile on linkedin and discover scotts. The increase in global cell therapy research, cuttingedge clinical trials and advances in laboratory operations all give rise to the importance of this straightforward, single platform with. Vysis vp2000 processor,the first consolidated workstation to automate deparaffinization, fish specimen pretreatment and routine slide staining,,,now you can perform deparaffinization, pretreatment, histologycytology staining, gbanding, special stains and routine slide washing with a single system.
Clinimacs prodigy cell manufacturing platform products. The cobe 2991 cell processor set the industry standard more than 30 years ago as a reliable laboratory tool for a variety of cell processing applications. A winning bid is a binding contract to purchase the item and abide by all terms and conditions set forth in the description of the item. Standard blood bank protocols using the cobe 2991 cell processor require several hours of preparation. Plastic tube rack for 10ml 15ml 50ml centrifuge tubes, bottle holder, refoldable. What is the price of a replacement cobe 2991 blood cell. Cobe 2991 cell processor at the university of pennsylvania. Six out 11 facilities use a stopping rule after digestion, mainly related to the number cobe 2991 cell processor except for one center that uses discontinuous gradient in tubes. Operate equipment involved in client specific cell processing procedures, including xuri w25 cell expansion system, cobe 2991 cell processor, sepax cpro, maxcyte gt, lovo. Compared with processes for traditional biologics, autologous cell therapy manufacturing is very manual and labor intensive. Used cobe cardiovascular, 2991 cell processor, cell saver for.
Terumo bct announced today that the spectra optia system mononuclear cell mnc collection protocol is now cleared by the u. Termubct cobe 2991 blood cell processing sets ref 90819 qty 12. This gives the cobe 2991 cell processor the ability to express fluids andor cells for removal or collection during centrifugation. It delivers consistent product quality in every batch enabling reproducible cell production. Please contact us via email for a freight quote or for local pickup.
It earned its enviable reputation for reliability, ease of use, instrument consistency, disposable set. Density gradient separation of bone marrow using the cobe. One goal of the study was to determine if tcd could be performed uniformly among study sites. Rapid bedside rejuvenation of red blood cell with an. Host instruments may be either nonautomated that is to say, they require manual operation to initiate function or semiautomated wherein at least some manual operation is necessary. Introduced more than 30 years ago, the cobe 2991 cell processor has set the. For the best chance of winning, increase your maximum bid. Patientspecific cell therapies are much different than off the shelf therapies such as traditional biologics. Contact us please submit the form below to contact a terumo bct representative and request more information. Nov 19, 2010 my experience is that when a patient is being transferred from another facility with cross matched rbc or other products.
Data from center 2 were available after the platelet wash, indicating that 65. The objective of this study was to verify if a bedside protocol for rejuvenating prbc and washing with the sorin xtra autologous cell salvage system could be used. Learn more about the cobe 2991 cell processor by contacting our cell processing team. Comparing cooling systems for the cobe 2991 cell separator used in the purification of human pancreatic islets of langerhans. None of the equipment posted for sale on is owned by medwow, should you have any questions regarding a specific item, please direct them to the appropriate seller by making use of the available communication channels on the items page. The cobe 2991 cell processor offers an alternative to laborintensive methods for the separation of cell products, such as manually layering blood over a density gradient separation medium using conical tubes. Consultation with the transfusion medicine service resulted in the decision to use washed prbcs to replace the blood loss from surgery.
The processing of stem cell concentrates from the bone marrow in aboincompatible transplants. The cobe 2991 cell processor offers an alternative to laborintensive methods. From timetested deglycerolization procedures to bone marrow processing, the cobe 2991 cell processor has been a solid solution for a variety of procedures for washing and concentrating cellular components. Density gradient separation of bone marrow using the cobe 2991 cell processor with the triplebag processing set article in transfusion clinique et biologique 161.
The operator may choose to run a protocol in either manual or automatic mode. Used cobe cardiovascular, 2991 cell processor, cell saver. Medical laboratory equipment for sale miga ready to buy. The clear centrifuge cover allows you to visually observe cell separation and fluid expression. Quality control of washed cells equipment pathlabtalk. The autolog autotransfusion system is a sophisticated device with an exceptionally effective design that provides autologous blood during surgical procedures. Heterogeneity of human pancreatic islet isolation around eur. The increase in global cell therapy research, cuttingedge clinical trials and advances in laboratory operations all give rise to the importance of.
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